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Profhilo Depth & Authenticity — BAP · 2.5–3.5mm

Profhilo works at Deep Dermis / Superficial Subcutaneous ~2.5–3.5mm (BAP depots). Pick any protocol below, or compare two head-to-head on the same cross-section.

Anatomical Skin-Layer Depth
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Aesthetic skin-layer depth diagram: Rejuran Healer, Profhilo, Botulinum Toxin, Juvelook / Lenisna, Skinvive / Belotero Revive Cross-section of facial skin from epidermis (0.1–0.3mm) through papillary dermis (to 1.5mm), reticular dermis (to 3.0mm), subcutaneous fat and the SMAS fibromuscular layer (4.5mm), showing each protocol's penetration vectors, thermal zones and injection depots. Highlighted: Profhilo — Deep Dermis / Superficial Subcutaneous ~2.5–3.5mm (BAP depots). INJECTABLES · 5 OF 12 Epidermis 0.1–0.3mm Papillary Dermis 0.3–1.5mm Reticular Dermis 1.5–3.0mm Subcutaneous Fat 3.0–4.2mm SMAS Fibromuscular · 4.5mm 0.3mm 1.5mm 3.0mm 4.5mm REJURAN PN · 0.5–1.5mm PROFHILO BAP · 2.5–3.5mm BOTOX IM >4.5mm JUVELOOK 1.0–4.0mm SKINVIVE 0.8–1.2mm Depth scale is expanded in the upper layers for legibility · focal depths per manufacturer specification
Depth chartSkin Depth Chart (Tap to Zoom) ↓ Download WebP
Profhilo target depth on the skin-layer cross-section: Deep Dermis / Superficial Subcutaneous ~2.5–3.5mm (BAP depots), pain 3/10, Singapore median S$950
Plate III — Profhilo (Intradermal PN / BAP Hybrid HA) on the skin-layer cross-section: Deep Dermis / Superficial Subcutaneous ~2.5–3.5mm (BAP depots). Pain 3/10, downtime 24–48 hrs small injection bumps, Singapore 2026 median S$950 (Per 2ml syringe (5-point BAP technique per side)).

IBSA Profhilo · Profhilo Structura

Profhilo

Thermally stabilised hybrid cooperative HA complex (32mg H-HA + 32mg L-HA) diffuses from 5 Bio Aesthetic Points per side for bio-remodelling.

IndicationsSkin laxity, crepiness, hydration, neck and décolletage

Audit a Profhilo quote · SG median S$950 →
Energy / Modality
Intradermal PN / BAP Hybrid HA
Target Anatomical Layer
Reticular Dermis 1.5–3.0mm
Subcutaneous Fat 3.0–4.2mm
Clinical Pain Index
3/10
Usually none — only 10 injection points.
Social Downtime
24–48 hrs small injection bumps
Evidence-Based Interval
2 sessions 4 weeks apart, then every 6 months

Counterfeit / Clone Machine Warning

Each authentic box carries a scannable QR / lot code from the authorised Singapore distributor (NeoAsia). Ask the doctor to scan it with you before opening.

  • ✓Box QR code scanned in front of you
  • ✓IBSA lot number and expiry match
  • ✓Syringe unopened until the procedure starts
Matched Accredited Clinics · Profhilo Full Dossier →

Comparison Matrix

Device Energy / Modality Target Layer Pain Downtime Interval SG Median
Pico Laser
Quanta · Candela · Cynosure · Fotona
 1064nm/532nm Picosecond Nd:YAG Epidermis 0.1–0.3mm (532nm) · Papillary Dermis 0.3–1.5mm (1064nm / MLA) 2/10 0 hrs (toning) · 24–48 hrs erythema (fractional) Every 2–4 weeks × 5–10 (toning) · every 4 weeks × 3–4 (fractional) S$350
Sylfirm X
Viol Co., Ltd. (Korea)
 300μm–4.0mm Bipolar Pulsed/CW RF Basement Membrane 0.3mm (PW) · Papillary & Reticular Dermis to 3.0mm+ (CW) 5/10 24–48 hrs erythema · pinpoint marks 2–3 days Every 4 weeks × 3–5 S$680
Thermage FLX
Solta Medical (Bausch Health)
 6.78 MHz Monopolar RF Reticular Dermis 1.5–3.0mm · Fibrous Septae to ~4.0mm 6/10 0–24 hrs mild erythema Annual single session (12–18 months) S$3,500
Ultherapy PRIME
Merz Aesthetics
 MHz Micro-Focused Ultrasound + Real-Time Ultrasound Imaging 1.5mm Dermis · 3.0mm Deep Dermis · 4.5mm SMAS Fibromuscular Layer 8/10 0 hrs social downtime · tenderness 1–2 weeks Annual single session (12–18 months) S$3,200
Sofwave
Sofwave Medical
 SUPERB Synchronous Ultrasound Parallel Beam Mid-Dermis Parallel Cylinder Zone 1.5mm (spares SMAS & subcutaneous fat) 6/10 0–24 hrs mild redness Annual single session (optional 6-month top-up) S$3,200
Potenza
Cynosure
 4-Mode Monopolar/Bipolar RF Microneedling 0.5mm–4.0mm Dual-Depth (Tiger Tip treats two dermal depths per pass) 6/10 24–72 hrs erythema · pinpoint marks Every 4–6 weeks × 3 S$850
Fotona 4D
Fotona
 2940nm Er:YAG + 1064nm Nd:YAG (4 modes) 0.1mm Epidermal Peel · 1.0–3.0mm Bulk Dermal Heating · Intraoral Mucosal Vector 4/10 0–24 hrs (SupErficial: 2–3 days fine peeling) Every 4–6 weeks × 3, then every 6 months S$750
Rejuran Healer
PharmaResearch (Korea)
 Intradermal PN (Polynucleotide 2%) Papillary Dermis 0.5–1.5mm (intradermal blebs) 7/10 3–5 days micro-bumps / subdermal papules (gun) · 1–2 days (manual) Every 3–4 weeks × 3, then maintenance every 6 months S$650
Profhilo
IBSA Derma (Switzerland)
 Intradermal PN / BAP Hybrid HA Deep Dermis / Superficial Subcutaneous ~2.5–3.5mm (BAP depots) 3/10 24–48 hrs small injection bumps 2 sessions 4 weeks apart, then every 6 months S$950
Botulinum Toxin
Merz · AbbVie (Allergan) · Ipsen / Galderma
 Botulinum Toxin Type A Neuromodulator Intramuscular (Masseter / Frontalis / Corrugator >4.5mm) · Intradermal Micro-Botox (0.8–1.2mm) 3/10 0 hrs · pinpoint bumps for 15–30 minutes Every 3–4 months (masseter 4–6 months) S$650
Juvelook / Lenisna
Vaim Co. (Korea)
 PDLLA + Non-Crosslinked HA Biostimulator Papillary to Reticular Dermis 1.0–1.8mm (Juvelook 50mg) · Subdermal 2.5–4.0mm (Lenisna 200mg) 5/10 1–3 days micro-papules Every 4–6 weeks × 2–3, then yearly S$780
Skinvive / Belotero Revive
AbbVie (Allergan) · Merz
 Microdroplet Intradermal HA (+ Glycerol) Superficial Intradermal Microdroplet Depot 0.8–1.2mm 4/10 24–48 hrs small bumps / redness Every 6 months S$980

Pillar II · Singapore 2026 Fair Price

Profhilo: fair S$780–S$1,150, median S$950

Per 2ml syringe (5-point BAP technique per side) · SGD incl. 9% GST. Profhilo under ~S$650 per syringe warrants checking the box QR code and lot number in front of you.

Transparent practices: Halley Medical Aesthetics · Bio Aesthetic Laser Clinic (Palais Renaissance)

Audit Your Profhilo Quote →

Clinic Dossier · Listed

Listed in Our Clinic Directory

Bio Aesthetic Laser Clinic (Palais Renaissance) is the one clinic in the dossier that lists Profhilo. Compare it with its closest medical aesthetic clinic peers.

Compare Bio Aesthetic Laser Clinic with 2 peers →

Section V · Before Profhilo

Pre-Procedure Washout & Post-Procedure Barrier Support

Injectables usually need no washout beforehand, but keep exfoliating acids, retinoids and spicule products off the injected area for 24–48 hours after.

Compare audited examples: retinoid, exfoliating acid, spicule →

After the session · Recovery & photoprotection

Compare barrier + SPF side by side →

Editorial guidance from common clinic practice, not medical advice: your treating doctor's pre- and post-care instructions come first.

How It Works

RF Microneedling & Intradermal Boosters

RF microneedling: heat delivered at the needle tipsInsulated microneedles enter the dermis to a set depth and release radiofrequency heat at their tips, leaving small coagulation zones that fibroblasts remodel with new collagen. RF microneedlingSylfirm X · Potenza · insulated needlesEpidermisPapillary dermis0.3–1.5 mmReticular dermis1.5–3.0 mmSubcutisneedle cartridgedepth set0.5–3.5mmfibroblasts · new collagenInsulated needles release RF at the tips: small coagulationzones heal, and fibroblasts lay down new collagen over weeksto months. The surface wounds are tiny channels.
Polynucleotides and skinboosters: intradermal microdropletsA fine needle places microdroplets of polynucleotide or hyaluronic acid product into the dermis, near the fibroblasts. PN / PDRN · skinboostersRejuran · Profhilo · Skinvive · injectedEpidermisPapillary dermis0.3–1.5 mmReticular dermis1.5–3.0 mmSubcutisintradermal microdroplets (about 1 mm)fibroblasts nearbyPN / PDRN (Rejuran): DNA fragments, proposed to supportfibroblasts and repair; clinical evidence is still emerging.HA boosters (Profhilo, Skinvive) hold water in the dermis.
Figure · RF microneedling vs. polynucleotide & HA skinboostersRF microneedling heats the dermis through needle tips; polynucleotide (PN / PDRN) and hyaluronic-acid boosters are placed as microdroplets in the dermis. Both depend on the skin’s own repair, so results build over weeks. Needle depth range is typical of current platforms; illustrative, not to scale.

Field Notes

Frequently Asked Questions

What skin depth and anatomical layer does Profhilo target?

Profhilo (Intradermal PN / BAP Hybrid HA) targets Deep Dermis / Superficial Subcutaneous ~2.5–3.5mm (BAP depots): Reticular Dermis (1.5–3.0mm), Subcutaneous Fat (3.0–4.2mm). Thermally stabilised hybrid cooperative HA complex (32mg H-HA + 32mg L-HA) diffuses from 5 Bio Aesthetic Points per side for bio-remodelling.

How painful is Profhilo, what is the downtime, and what is the evidence-based session interval?

Pain index 3/10. Usually none — only 10 injection points. Downtime: 24–48 hrs small injection bumps. Interval: 2 sessions 4 weeks apart, then every 6 months.

How do I verify an authentic Profhilo syringe and what is a fair price in Singapore?

Box QR code scanned in front of you; IBSA lot number and expiry match; Syringe unopened until the procedure starts. Each authentic box carries a scannable QR / lot code from the authorised Singapore distributor (NeoAsia). Ask the doctor to scan it with you before opening. Beauty.net's 2026 Singapore benchmark for Profhilo (Per 2ml syringe (5-point BAP technique per side)) is a fair range of S$780–S$1,150 with a median of S$950, incl. 9% GST.